A-328 Urine Toxicology Screening: Tetrahydrocannabinol Positivity Patterns at an U.S. Urban Tertiary Care Children's Hospital

Abstract Background Given the recent legalization of recreational and medical marijuana in different states, there is an increasing exposure children teenagers to products which has led increase health care visits hospitalizations. Our drug testing algorithm uses immunoassay test for initial urinary screening (UDS) followed by automatic confirmatory only when a positive UDS result obtained. The performed in-house detects major metabolites delta9- tetrahydrocannabinol (THC), main psychoactive component marijuana. In contrast, liquid chromatography-tandem mass spectrometry (LC-MS/MS) more specific towards THC carried out external lab. light ongoing trend cases fact that cross-reactivity with non-cannabinoid compounds uncommon, we aim assess necessity tests our patient population evaluate its impact on management. Methods We conducted retrospective study trends cannabinoid hospital-related encounters age, gender, incidence other drugs, among campus satellites (November 2021–October 2022). were cannabinoids further evaluated their agreement testing. Results Cannabinoid account 62.0% (504/813) all locations 84% (425/504) did not classes. Among this population, 92.7% (467/504) are adolescent age (≥13 years), whereas 7.3% (37/504) (<13 years). Female comprises 56.0% (217/504) male, 43% (271/504) cases. true rate was 99.6% (465/467) 94.6% (35/37) adolescents children, respectively. Clinical decisions made after before as send takes few days receive result. Conclusion evidence-based approach demonstrates unnecessary group due high positivity (99.6%). Discontinuing will eliminate workload reduce healthcare costs. On hand, continue these exposures mainly considered unintentional require investigation.